Molecular Details
DICL_CP_0347697
- 4-chloro-N-(2-thiophen-2-ylimidazo[1,2-a]pyridin-3-yl)benzamide
Basic Molecular Information
Basic Information
DICL ID
DICL_CP_0347697
PubChem CID
Molecular Formula
C18H12ClN3OS Molecular Weight
353.834 g/mol
Synonyms/Alias
N/A (Not available)
InChI Key
AZKMWHRDICVYEI-UHFFFAOYSA-N
InChI
InChI=1S/C18H12ClN3OS/c19-13-8-6-12(7-9-13)18(23)21-17-16(14-4-3-11-24-14)20-15-5-1-2-10-22(15)17/h1...
IUPAC Name
4-chloro-N-(2-thiophen-2-ylimidazo[1,2-a]pyridin-3-yl)benzamide
CAS Number
N/A (Not available)
Structure Information
Chemical Structure Visualization
SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF
24 27 0 0 0 0 0 0 0 0999 V2000
-7.0700 -0.6062 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0
-5.6128 -0.2504 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-5.1923 1...
Experimental Data
Activity Data
Target Ion Channel
Gamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta
Uniprot Accession Number
Function
Agonist
Species
Rattus norvegicus (Rat)
IC50
N/A (Not available)
EC50
EC50: 970 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)
Experimental Conditions
pH
Extracellular solution pH 7.4/Intracellular solution pH 7.2
Holding Potential
Not mention mV
Temperature
Not mention
Test Method
Patch-clamping
Test Species
HEK 293 cell
Binding Information
Binding Site
Not specified
Binding Site Residue
Not specified
Disease Information
Related Disease
Not specified
References
Computed Properties
Heavy Atom Count
24
Rotatable Bonds
3
logP
4.9685
Complexity
97.9102
TPSA (Ų)
46.4
H-Bond Donors
1
H-Bond Acceptors
4
Ring Count
4